Abstract
Oxidative stress is a phenomenon that occurs in the body when there is an imbalance between the production of oxygen reactive species (free radical) and antioxidant molecules. Rusting of iron takes place on continuous expo- sure to oxygen. Likewise, the accumulation of free radicals in the body results in oxidative stress which results in tissue damage and thus leads to various diseases. Rasayana Chikitsa helps in the attainment of good quality of rasa. Guduchi [Tinospora cordifolia (Willd) Miers. F. & Thomas] is a marvellous drug having Rasayana property belonging to the Menispermaceae family enriched with antioxidant molecules. It has the power to detoxify, reju- venate and boost the immune system. ‘Guduchi’ the word itself conveys the meaning ‘which protects the body from diseases.Tinospora cordifolia is well known for its properties such as antioxidant, anti-hyperglycemic, anti-hyperlipidemic, hepato-protective, cardio-protective, neuroprotective, osteo-protective, radio-protective, anti-anxiety, adaptogenic agent, analgesic, anti-inflammatory, antipyretic, thrombolytic agent, anti-diarrheal, anti-ulcer, anti-microbial and anti-cancer agent. An attempt has been made to review the role of Guduchi in the pre- vention of oxidative stress based on the different studies carried out regarding the antioxidant activity of Guduchi. Studies proved that the Phenolic content of Guduchi is meant for its antioxidant activity. Based on Ayurvedic the- ories, Guduchi acts at the level of Agni and helps in the formation of the fine quality of rasa. Also, prevent the accumulation of a toxic substance called Ama that which is considered as the root cause of disease. Keywords: Guduchi, free radical, Oxidative stress, Antioxidant activity
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