Abstract
Single topical application of jute batching oil (JBO-P) elevated the status of enzyme GSSG-reductase in mouse skin and multiple applications produced a persistent increase in the enzyme levels. Also an increase in NADPH-dependent GSSG-reductase activity was registered after single topical application of known carcinogenic polyaromatic hydrocarbons (PAHs), e.g. benzo(a)pyrene (BaP), 7,12-dimethyl-benzanthracene (DMBA) and 3-methylcholanthrene (3-MC). This suggests that the change in GSSG-reductase activity induced by JBO-P is intrinsic to its tumorigenic activity rather than the toxic effect of the oil. Pretreatment of mouse skin with diethylmaleate (DEM), an SH-inactivating agent, increases the latent period of JBO-P induced tumorigenesis. No tumour was recorded in animals belonging to Group IV (DEM + JBO) while in animals belonging to Group II (JBO-P alone) 100% tumorigenesis was recorded during the period of study (i.e. up to 20 wk).
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