Abstract
My research interests are twofold. The first is to define the biochemical and molecular mechanisms that regulate hematopoietic cell development. In particular, the role that the cytokine interleukin-2 (IL2) plays in regulating the development and selection of lymphocyte progenitor cells, and in myelopoiesis are primary areas of research. The second is to understand the role that gamma delta T cells play in pathogen-induced immune responses and autoimmunity. Their involvement in the immune response to the intracellular bacteria Listeria monocytogenes in mice and Mycobacteria tuberculosis (Mtb) in humans, in T cell-mediated inflammatory bowel disease in humans, and the nature of the antigens they recognize during these responses are major areas of interest. Research material includes patient-derived tissues as well as both conventional and genetically engineered (transgenic) strains of mice.
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