Abstract

The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka. The journal also has a website. Free full text access is available for all readers.The Sri Lanka Journal of Child Health is now indexed in SciVerse Scopus (Source Record ID 19900193609), Index Medicus for South-East Asia Region (IMSEAR), CABI (Centre for Agriculture and Bioscience International Global Health Database), DOAJ and is available in Google, as well as Google Scholar.The policies of the journal are modelled on the Committee on Publication Ethics (COPE) Guidelines on Principles of Transparency and Best Practice in Scholarly Publishing. Sri Lanka Journal of Child Health is recognised by the International Committee of Medical Journal Editors (ICMJE) as a publication following the ICMJE Recommendations.

Highlights

  • Folic acid (FA) pregnancy may profoundly cardiovascular morphogenesis.deficiency in affect fetal

  • There was no difference between supplemented FA consumption during pregnancy between the two groups

  • The study reveals that supplemented FA consumption during pregnancy significantly reduces the risk of congenital heart disease (CHD)

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Summary

Introduction

Folic acid (FA) pregnancy may profoundly cardiovascular morphogenesis.deficiency in affect fetal. Folic acid (FA) pregnancy may profoundly cardiovascular morphogenesis. The incidence and types of congenital heart disease (CHD) vary among countries[1]. The incidence of CHD is approximately 0.5%-0.8% of live births and is higher in spontaneous abortions, stillborns and preterm babies[2,3]. Aetiology of most CHD is unknown and combined genetic and environmental factors may be involved[2]. Recent studies show that consumption of folic acid (FA) in the periconceptional period may play an important role in cardiac morphogenesis[4]. It is converted to dihydrofolates and tetrahydrofolates in the liver and takes an active part in cell division, synthesis, repair, methylation of deoxyribonucleic acid (DNA) and as cofactor of other vital functions[5,6]

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