Abstract
Quercetin, a ubiquitous flavonoid in plants, inhibited the incorporation of [ 32P]inorganic phosphate ( 32P i) into phospholipid of HeLa cells enhanced by 12- O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter. Among the flavonoids tested luteolin was the most effective in inhibiting the action of TPA. Studies on structure-activity relationships demonstrated that more hydroxylated flavones and flavonols had stronger inhibitory effects. Quercetin and luteolin also inhibited enhancement of 32P i-incorporation into phospholipid by dihydroteleocidin B, another potent tumor promoter. The inhibitory effect of quercetin on the biological action of tumor promoters is interesting in relation to the non-carcinogenicity of this flavonoid in animals, in spite of its mutagenicity.
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