Abstract
BackgroundLiver cancer (HCC) ranks as the fifth most prevalent cancer worldwide and is ranked third as a common cause of death due to cancer. The benefit of Fibroscan in assessing the risk of developing liver cancer that was evaluated in this work was not fully demonstrated. The aim of this work was to study the role and clinical significance of Fibroscan for early detection of liver cancer in hepatitis C patients with cirrhosis.ResultsAs regards binary logistic regression for predictors of HCC, it was found that Child C, AST, Fibroscan, and AFP were predictors for developing HCC. Liver stiffness values were significantly high in all groups, and the specific cutoff value for hepatocellular carcinoma detection was above 24 kPa in hepatitis C virus patients. Therefore, liver stiffness of more than 24 kPa can be considered as an independent risk factor for the development of liver cancer in HCV patients.ConclusionLiver stiffness of more than 24 kPa was an independent risk factor for developing new liver cancer in HCV patients.
Highlights
Liver cancer (HCC) ranks as the fifth most prevalent cancer worldwide and is ranked third as a common cause of death due to cancer
Nineteen patients (76%) in group I and 10 patients (40%) in group II presented by ecchymosis, and hepatomegaly was detected in 2 patients (8%) in group I and 6 patients (24%) in group II; feeling of hard liver was detected in 10 hepatocellular carcinoma (HCC) patients (40%) compared to Hepatitis C virus (HCV) cirrhotic patients without HCC with a significant statistical difference
Was detected in 18 patients (72%) in group I and 20 patients(80%) in group II, while 15 patients (60%) in group I and 10 patients (40%) in group II suffered from abdominal pain; while 20 patients (80%) in group I and 16 patients (64%) in group II suffered from easy fatigability, 22 patients (88%) in group I and 20 patients (80%) in group II suffered from loss of weight
Summary
Liver cancer (HCC) ranks as the fifth most prevalent cancer worldwide and is ranked third as a common cause of death due to cancer. For improvement in the fate of liver cancer, adequate treatment after early detection is important To this end, it is critical to identify high-risk groups for liver cancer and to conduct appropriate screening in the clinical practice of chronic liver disease [9, 10]. Liver cirrhosis has been evaluated by liver biopsy, as the histology is the gold standard for quantitative fibrosis assessment; but liver biopsy is associated with several problems such as invasiveness, sampling errors, and diagnostic differences between pathologists. This makes it unpopular among patients and impractical for serial assessments of patients with chronic liver disease. An accurate quantification of the degree of liver fibrosis is necessary for prognosis and guiding surveillance [15]
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