Abstract
BackgroundIt is hypothesized that dietary supplementation with Fenugreek modulates glucose homeostasis and potentially prevents diabetes mellitus in people with prediabetes. The objective of present study is to determine whether Fenugreek can prevent the outcome of T2DM in non diabetic people with prediabetes.MethodsA 3-year randomized, controlled, parallel study for efficacy of Fenugreek (n = 66) and matched controls (n = 74) was conducted in men and women aged 30–70 years with criteria of prediabetes. Fenugreek powder, 5 g twice a day before meals, was given to study subjects and progression of type 2 diabetes mellitus (T2DM) was monitored at baseline and every 3 months for the 3-year study.ResultsBy the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls. The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly. It was observed that controls had 4.2 times higher chance of developing diabetes compared to subjects in the Fenugreek group. The outcome of diabetes in Fenugreek group was positively associated with serum insulin and negatively associated with insulin resistance (HOMA IR).ConclusionsDietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.
Highlights
It is hypothesized that dietary supplementation with Fenugreek modulates glucose homeostasis and potentially prevents diabetes mellitus in people with prediabetes
Anthropometric measurements At baseline and at the end of 3 years, there were no significant differences in body weight, body mass index (BMI), waist-to-hip ratio (WHR), Systolic blood pressure (SBP) and Diastolic blood pressure (DBP) within control and Fenugreek groups (Table 3)
Progression to diabetes It was observed that the conversion rate from impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) to diabetes by the end of 3 years reduced significantly in Fenugreek group when compared to controls (Fig. 2)
Summary
It is hypothesized that dietary supplementation with Fenugreek modulates glucose homeostasis and potentially prevents diabetes mellitus in people with prediabetes. The objective of present study is to determine whether Fenugreek can prevent the outcome of T2DM in non diabetic people with prediabetes. An epidemic of diabetes threatens the health of a large number of individuals in developed and developing countries alike [1]. The epidemic of prediabetes is likely to compound the existing diabetes crisis as many individuals with IGT will develop type 2 diabetes mellitus (T2DM) in the future. It is estimated that approximately 316 million people worldwide are with IGT and this is predicted to rise to 471 million by 2035. The use of medicinal plants in most developing countries, as a normative basis for the maintenance of good health, has been observed extensively. There is a growing global interest in herbal and other forms of traditional medicine [5]
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