Abstract
The hypothalamus,which has nutrient sensitive neurons perceiving the nutritional status of body,plays a key role in the maintenance of energy homeostasis. As energy signal,fatty acids (FAs) can affect the activity of hypothalamic FA-sensitive neurons, and modulate food intake, insulin secretion and hepatic glucose output, by changing the membrane potential, regulating the ion channels, and affecting the secretion of neurotransmitters. Moreover FAs metabolites in the neurons also paticipate in the lipid sensing of hypothalamus. Overload and dysfunction of their metabolism impair nervous control of energy homeostasis, and contribute to development of obesity and type 2 diabetes. Key words: Fatty acids; Central nervous system; Lipid-sensing; Energy homeostasis; Hypothalamus
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