Role of Eye Platelet-Rich Plasma in the Treatment of Ocular Surface Disorders

Abstract

The use of blood derivatives represents an alternative therapeutic approach that is gaining interest in regenerative medicine dueto its potential to stimulate and accelerate tissue healing. Platelet-rich plasma is the highly concentrated form of autologoushuman platelets in a small amount of plasma which contains important growth factors and plasma proteins that play a significantrole in the wound healing process by epithelial differentiation and collagen bundle organization.In this article, we aim to provide an update on the current literature regarding the eye platelet-rich plasma, its methods ofpreparation, physiological and biochemical properties, its clinical applications, safety and efficacy as compared to other bloodderived products, etc. In ophthalmology, this product is being used in the management of symptomatic dry eyes, corneal ulcers,periocular chemical and thermal burns, idiopathic macular hole, skin rejuvenation post blepharoplasties and more recentlyactinic elastosis in the lower eyelid regions. The role of eye platelet-rich plasma in ocular surface disorders has been sparselystudied in literature with more studies and reports on the application of autologous and allogeneic serum eye drops therefore, itbecomes very important to update ourselves with more studies in this topic to prove the efficiency of this blood-derived product.