Abstract
Influenza virus infection is a major health care concern associated with significant morbidity and mortality worldwide, and cause annual seasonal epidemics and pandemics at irregular intervals. Recent research has highlighted that viral components can be found on the extracellular vesicles (EVs) released from infected cells, implying a functional relevance of EVs with influenza virus dissemination. Therefore, exploring the role of EVs in influenza virus infection has been attracting significant attention. In this review, we will briefly introduce the biogenesis of EVs, and focus on the role of EVs in influenza virus infection, and then discuss the EVs-based influenza vaccines and the limitations of EVs studies, to further enrich and boost the development of preventative and therapeutic strategies to combat influenza virus.
Highlights
Influenza virus, a single-stranded negative-sense RNA virus, belongs to Orthomyxoviridae family, and can infect the nasal and tracheal airways, and spread throughout the upper and lower respiratory tract (Tumpey and Belser, 2009)
Current evidences suggest EVs play an important role in influenza virus infection
During the process of influenza virus infection, EVs can deliver virus particles that serve as regulators of host defense and mediators of immune evasion, or that serve as antigens of innate immune receptors to stimulate host defense and immunity
Summary
A single-stranded negative-sense RNA virus, belongs to Orthomyxoviridae family, and can infect the nasal and tracheal airways, and spread throughout the upper and lower respiratory tract (Tumpey and Belser, 2009).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
