Role of Exercise Intensity on Intramyocelluar Lipid Level After Exercise in Subjects with Moderate Insulin Resistance

Abstract

It is known that the increased intramyocellular lipid (IMCL) levels observed in obese subjects are closely associated with insulin resistance (IR) in muscle 1). Interestingly, some reports suggested low intensity exercise (LIE) decreased IMCL and improved IR 2). On the other hand, a few reports showed vigorous intensity exercise (VIE) improved IR, but increased IMCL level 3) 4). This phenomenon is a reminiscent of endurance-trained athletes, who possess a high oxidative capacity and enhanced insulin sensitivity, also have higher IMCL content known as athlete’s paradox (AP) 5) 6). From these findings, we hypothesized exercise intensity is one of the determinants of AP.