Role of Essential Oil of Mentha Spicata (Spearmint) in Addressing Reverse Hormonal and Folliculogenesis Disturbances in a Polycystic Ovarian Syndrome in a Rat Model.

Mahmood Sadeghi Ataabadi,Sanaz Alaee,Soghra Bahmanpoor,Mohammad Jafar Bagheri

doi:10.15171/apb.2017.078

Mahmood Sadeghi Ataabadi, Sanaz Alaee + Show 2 more

Open Access

https://doi.org/10.15171/apb.2017.078

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Abstract

Purpose: Given the antiandrogenic effects of spearmint, in this study we evaluated the effects of its essential oil on polycystic ovarian syndrome in a rat model.Methods: Female rats were treated as follows: Control, normal rats which received 150 mg/kg spearmint oil or 300 mg/kg spearmint oil, or sesame oil; and PCOS-induced rats which received 150 mg/kg spearmint oil or 300 mg/kg spearmint oil, or sesame oil. Then the animals were killed and the levels of LH, FSH, testosterone and ovarian folliculogenesis were evaluated.Results: Spearmint oil reduced body weight, testosterone level, ovarian cysts and atretic follicles and increased Graafian follicles in PCOS rats.Conclusion: Spearmint has treatment potential on PCOS through inhibition of testosterone and restoration of follicular development in ovarian tissue.

Highlights

Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism and elevated level of oxidative stress and, often, obesity, abnormal menstrual cycle, insulin resistance and oligomenorrhea or anovulation.[1]
Purpose: Given the antiandrogenic effects of spearmint, in this study we evaluated the effects of its essential oil on polycystic ovarian syndrome in a rat model
The weight of animals in the PCOS-induced group and in the PCOS-induced groups that received spearmint oil (150 mg/kg) and sesame oil was significantly higher than that of the control group (p=0.006, p=0.004 and p

Summary

Introduction

Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism and elevated level of oxidative stress and, often, obesity, abnormal menstrual cycle, insulin resistance and oligomenorrhea or anovulation.[1]. Results: Spearmint oil reduced body weight, testosterone level, ovarian cysts and atretic follicles and increased Graafian follicles in PCOS rats. Results and Discussion The body weight, level of LH and FSH, testosterone and the number of primordial, primary, secondary, Graafian and atretic follicles and corpus lutea was not different among control and rats which received spearmint oil or sesame oil (p>0.05).

Results

Conclusion