Abstract
Role of Epidermal Growth Factor in Oral Lichen Planus
Highlights
Lichen planus (LP) is an inflammatory mucocutaneous condition with characteristic clinical and histopathological findings
Epidermal Growth Factor (EGF) is the prototypical member of a family of peptide growth factors that activate the EGFR, Despite the strong association of EGFR over expression with oral carcinogenesis, few studies have analyzed its expression in OLP
This study revealed that there is a statistically very high significant difference between OLP group and control group as regard serum level of EGF (p-value ≤ 0.001)
Summary
Lichen planus (LP) is an inflammatory mucocutaneous condition with characteristic clinical and histopathological findings. OLP is the mucosal counterpart of cutaneous LP which is a chronic mucocutaneous disorder of stratified squamous epithelium that affects oral and genital mucous membranes, skin, nails, and scalp. Epidermal Growth Factor (EGF) is the prototypical member of a family of peptide growth factors that activate the EGFR, Despite the strong association of EGFR over expression with oral carcinogenesis, few studies have analyzed its expression in OLP.
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