Role of endothelium damage factors in the pathogenesis of cardiomyopathy surge in athletes sports

Abstract

The cardiovascular system experiences the greatest stress when exercising. This leads to exhaustion and dysfunction of compensatory-adaptive mechanisms, forms a state of acute physical overstrain, increases the risk of cardiovascular disease. Endothelial dysfunction in athletes due to oxidative stress under high training loads. Risk factors include endothelial da­mage hypercholesterolemia, hyperhomocysteinemia, elevated levels of cytokines. To clarify the Ethio-features overvoltage held definition of cardiomyopathy endothelium damage factors of sports athletes. Surveyed 112 people aged 17-25 years, boys 1 level and candidates for master of sports. ECG signs of cardiomyopathy overvoltage on change trailing portion of ventricular complex alone and disrupt heart rhythm found in 36 (32%) athletes who entered the primary group. Group of comparison comprised 38 athletes without electrocardiographic signs of cardiomyopathy. Conducted definition damaging endothelium factors: homocysteine, cytokines IL-8, IL-4, TNF-α, lipid spectrum, including modified (oxidized) lipoproteins. Revealed in athletes with electrocardiographic signs of cardiomyopathy overexertion, an increase in low-density lipoprotein along with an increase in the level of homocysteon and anti-inflammatory cytokines, causing endothelial dysfunction, can play a significant role in the pathogenesis of cardiomyopathy overexertion. Accordingly, prevention and drug therapy of cardiomyopathy overexertion in athletes should be aimed at reducing the factors that cause endothelial dysfunction, namely, hyperhomocysteinemia, increase in the level of cytokines (TNF-α and IL-8) and modified oxidized lipoproteins.