Abstract
The prevalence of intraventricular conduction delays in patients with left ventricular (LV) systolic dysfunction and chronic heart failure (CHF) has been estimated at 30%-50%. These abnormalities negatively affect both systolic and diastolic ventricular function causing uncoordinated contractions between the left and the right ventricles and between the various segments of the LV wall [1-9], and have been associated with an unfavorable prognosis [10-15]. The most common expression of the presence of intraventricular conduction delays is left bundle branch block (LBBB). Cardiac resynchronization by LV or biventricular pacing has recently been introduced to treat patients with chronic heart failure (CHF) who respond poorly to optimal medical therapy, LV systolic dysfunction, and intraventricular conduction delays, based on the hypothesis that LV pacing, possibly associated with right ventricular pacing, can restore the physiological coordination of ventricular contraction.
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