Role of Drugs in the Presence of HLA-B*51 and HLA-B*51 Subtypes in Iraqi Behcet’s Disease Patients

Abstract

Background: Behcet’s disease (BD) is a chronic, progressive disease with an unknown cause that affects numerous organs and systems. Several alleles of HLA-B*51(HLA-B*5101, HLA-B*5108, HLA-B*5105 and HLA-B*5104) are found to be associated with Behcet’s disease. Objective:. Detection of the most common HLA-B*51 subtypes in Iraqi Behcet’s disease patients. Patients and methods: This study compared 60 patients with BD to 30 healthy people as a control group from December 2020 to the end of May 2021. Their blood samples were taken in order to test for the presence of HLA-B*51 and HLA-B*51 subtypes using real-time PCR (rtPCR) and the sequence-specific primers technique (PCR-SSP). Results: HLA-B*51 frequency was highly significant among patient group 49 (81.70%) in comparison to the control group, and the most frequent subtype was HLA-B*5105 22 (36.67%) in Iraqi patients. Conclusion: In Iraq, there may be a link between HLA-B*51 frequency and Behcet’s illness patients. HLA-B5105 was the most common subtype in Iraqi patients.