Role of DNA Methylation in Development of Cardiovascular Diseases, Resulting in a Sudden Cardiac Death (Review)

A.A Ivanova,A.A Gurazheva,S.V Maksimova

doi:10.17691/stm2022.14.1.08

Abstract

Role of DNA Methylation in Development of Cardiovascular Diseases, Resulting in a Sudden Cardiac Death (Review)

Highlights

Despite a recent significant progress in prevention of ischemic heart disease (IHD) and cardiac failure, the problem of high mortality from cardiovascular diseases has not yet been solved [1, 2]
According to recommendations of the European Society of Cardiology, the “sudden cardiac death” term should be used in case of a sudden lethal outcome, considering the following: whether the past history of the deceased contains an indication of a congenital or acquired potentially lethal heart disease; whether the autopsy revealed a cardiac or vascular anomaly which might have caused death; whether autopsy revealed no extracardiac causes of death [1]
sudden cardiac death (SCD) may have a predisposing substrate, when there is a trigger, which develops ventricular tachycardia or fibrillation, less often bradyarrhythmia, asystole, or complete atrioventricular block [2, 6, 7]

Summary

Introduction

Despite a recent significant progress in prevention of ischemic heart disease (IHD) and cardiac failure, the problem of high mortality from cardiovascular diseases has not yet been solved [1, 2]. According to the results of a pilot epigenome-wide association study [18], there were 429 differentially methylated regions (222 hypomethylated and 207 hypermethylated) identified in patients with IHD and individuals from the control group; there was a panel of loci with the most different methylation status created, it included mainly the genes of the HLA system and inflammation.

Results

Conclusion