Abstract
Cytoplasmic dynein is a large, eukaryotic motor protein complex composed of heavy, intermediate, light intermediate, and light chain subunits. The motor domain of dynein has been well characterized, however in the tail domain there are almost 300 amino acids of disorder that remain missing from resolved dynein structures. This disorder lies in dynein's intermediate chain (IC), the key protein in dynein's cargo attachment subcomplex, involved in binding dynein's light chain subunits as well as various non-dynein regulatory proteins.
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