Abstract
Abstract : We found that DIP 1, a novel 45 Kda nuclear protein recently identified in our laboratory, is frequently expressed in primary human breast cancers and breast cancer cell lines. However the level of expression 0 DIP 1 in breast cancer cells appears to be lower than that in normal mammary epithelial cells. Overexpression of DIP 1 in MCF-7 human breast cancer cells inhibited colony formation and cell proliferation but did not inhibit specific phases of the cell cycle. In mechanistic studies we found that DIP 1 inhibits the transcriptional activities of the cyclin Dl, c-fos, SRE, and NF Kappa B promoters.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
