Abstract
The synthesis of antibodies and nonspecific immunoglobulins in mono- and mixed cultures of immune lymph nodes and intact bone marrow after removal of adherent cells or T cells was studied by a radioisotope method using immunosorbents. Treatment of the lymph node cell population with anti-θ serum depressed antibody synthesis to 30%, whereas removal of the adherent cells depressed it to 70%. In mixed cultures of immune lymph node cells, after removal of adherent cells, and intact bone marrow cells no effect of stimulation of immunoglobulin synthesis was observed, but treatment of immune lymph node cells with anti-θ serum doubled this effect. The possible mechanisms of the effect of stimulation of immunoglobulin synthesis in mixed cultures are discussed and it is concluded that cooperation between individual types of cells is essential in the productive phase of the immune response.
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