ROLE OF DIFFERENT METABOLIC SYNDROME COMPONENTS ON THE RISK TO DEVELOP SLEEP APNOEA: PP.32.275

Abstract

Objective: In various clinical studies, apnoea sleep disorders have been associated with different cardiovascular and metabolic abnormalities. The aim of this analysis was to assess the relation between a multivariable apnoea prediction index, metabolic syndrome (MS) and its single components in an unselected sample of adult male population. Design and Method: The relationship between MS (AHA 2005 criteria) and a high apnoea risk (HAR) evaluated by a multivariable apnoea prediction index higher than 0.5, was investigated in 612 (mean age ± SD = 59.7 ± 6.4 years) participants at the 2002–04 Olivetti Heart Study follow-up. Results: The prevalence of MS and of HAR were respectively 36.6% (n = 224) and 60.8% (n = 372). MS and HAR were strongly associated (χ2 = 26.3; p < 0.0001). The prevalence of HAR increased gradually with increasing number of MS components. (χ2 = 36.4; p < 0.0001), the higher the MS score, the higher the prevalence of HAR. Using a logistic regression analysis with apnoea risk as dependent variable and MS components and age as independent factors, hypertension (blood pressure > 130/85 mmHg or treatment) and central adiposity (waist circumference > 102 cm) remained the only determinants of HAR with odds ratio (95%CI) of respectively 2.57 (1.53 to 4.33) and 3.84 (2.47 to 5.98). Conclusion: In this sample of adult male population the prevalence of high apnoea risk was related to both presence and severity of metabolic syndrome. Among different components of MS, blood pressure and central adiposity were the factors more strongly associated to the risk to be affected by sleep apnoea disturbances.