Abstract
Aims: The impact of diet on the lipid profile of offspring of HFD-induced obese rats was studied. Methodology: (20) Adult female rats were divided into Group A (control) and B (experimental) and received NRC and HFD respectively for 16 weeks. Group B rats with BMI >0.50 g/cm2 were considered obese. NRC fed Adult male rats was introduced to each group, to ensure mating and pregnancy after 16 weeks of feeding. The offspring of the parent’s rats in each group were fed with NRC for 12 months. The parents blood after weaning and that of their offspring at 4, 8 and 12 months were collected via retro-orbital puncture into separate heparinized tube. The plasma from the blood was analyzed for lipid profile. Results: The experimental had higher Cholesterol, triglyceride and HDL compared to the control. At 4 and 12 months of age, the offspring of the experimental had lower triglyceride and LDL compared to that of control. The offspring of the experimental had higher HDL compared to that of control at 8 months of age. Conclusion: If offspring of obese rats are placed on NRC throughout their life time, the consequence of maternal obesity on their lipid profile may not manifest.
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