Abstract
Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. GVHD is caused by donor T cells that recognize and react to recipient histocompatibility differences, resulting in significant morbidity and mortality. The pathophysiology of GVHD is complex, which occurs in three phases: induction phase, activation phase and effector phase. Numerous studies have demonstrated that GVHD involves multiple inflammatory cells and cytokines, in particular of antigen presenting cells, chemokines and T cell subsets. This review will discuss roles of a special antigen presenting cell: dendritic cell and chemokines in T cell-mediated acute GVHD.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
