Abstract
Cytochrome P450s (CYPs) are the largest enzyme family involved in NADPH- and/or O2-dependent hydroxylation reactions across all the domains of life. In plants and animals, CYPs play a central role in the detoxification of xenobiotics. In addition to this function, CYPs act as versatile catalysts and play a crucial role in the biosynthesis of secondary metabolites, antioxidants, and phytohormones in higher plants. The molecular and biochemical processes catalyzed by CYPs have been well characterized, however, the relationship between the biochemical process catalyzed by CYPs and its effect on several plant functions was not well established. The advent of next-generation sequencing opened new avenues to unravel the involvement of CYPs in several plant functions such as plant stress response. The expression of several CYP genes are regulated in response to environmental stresses, and they also play a prominent role in the crosstalk between abiotic and biotic stress responses. CYPs have an enormous potential to be used as a candidate for engineering crop species resilient to biotic and abiotic stresses. The objective of this review is to summarize the latest research on the role of CYPs in plant stress response.
Highlights
Cytochrome P450s belong to the oxidoreductases class of enzyme, which represents one of the largest enzyme families containing heme-thiolate as a cofactor
Cytochrome P450s (CYPs) are versatile enzymes involved in multiple processes of plant growth and development and play an essential role in stress response
The CYP genes involved in desirable plant functions can potentially be used to improve crop varieties, especially for stress tolerance [123]
Summary
Cytochrome P450s (hereafter referred to as CYPs) belong to the oxidoreductases class of enzyme, which represents one of the largest enzyme families containing heme-thiolate as a cofactor. CYPs have been found to play a major role in directly involved in the secondary metabolism of plants, facilitating detoxification of external hormone signaling, thereby regulating plant response under stress conditions [8,9,10]. CYP genes involved in plant stress response have been identified Such genes result of the advancement of sequencing technology and computational capacity in the last decade. Sequencing (GBS) combined with several fine mapping methods helped to deduce the function of CYPs. Specific CYP genes involved in plant stress response have been identified. Specific CYP genes involved in plant stress response have been identified Such CYP genes have a great potential to be used as candidates for engineering crop species resilient to biotic and abiotic stress. The objective of this review is to summarize the research on the involvement of CYPs in the plant stress response
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