Abstract
Role of Cyclodextrins in New Antimycobacterial Formulations
Highlights
Tuberculosis is one of the deadliest infectious diseases killing annually 1.5 million people worldwide
We have suggested that complexation of cholesterol by cyclodextrins can be used to increase the permeability of the mycobacterial cell wall for penetration by antimycobacterial compounds
Β-cyclodextrin, one of the naturally occurring cyclodextrins, seems to enhance antituberculosis activity of the associated oxadiazole derivative, while sulfobutyl ether of β-cyclodextrin does not have this influence. This observation might be explained by the fact that sulfobutyl ether of β-cyclodextrin possesses certain level of charge of the molecule due to the presence of sulfobutyl ether groups, which makes it less suitable for cholesterol complexation than simple β-cyclodextrin
Summary
Tuberculosis is one of the deadliest infectious diseases killing annually 1.5 million people worldwide. The closest by composition known microparticulate systems are gelatin based microparticles covered with manosyl groups and loaded with isoniazid [9], and microspheres based on alginate-chitozan used for transport of different anti-tuberculosis drugs [10]. In the field of new anti-mycobacterial drugs, recently, many groups of researchers have proposed entities from different chemical classes: thiolactomycins [11], benzothiazones [12], substituted quinolinyl chalcones [13], cinnamic derivatives [14].
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