Role of Cyclin Polymorphisms in Predicting Outcome of 5-Fluorouracil-Based Chemotherapy in Colorectal cancer: one piece in a complex puzzle

Abstract

1671 ISSN 1462-2416 10.2217/PGS.13.138 © 2013 Future Medicine Ltd Pharmacogenomics (2013) 14(14), 1671–1674 “While the insight provided from studying the cell cycle and its associated proteins has advanced our understanding of the complex network and crossover between signaling pathways in both normal and cancer cells and has led to new drug targets and novel combination chemotherapies, the true importance of these molecules in mediating drug response still remains to be fully established.”