Abstract
To study the role of cyclin D1, p53 Protein and DNA ploidy in judging the degree of malignancy and prognosis of lung cancer. Paraffin-embedded specimens from 40 lung cancer patients and 15 paracancerous normal lung tissues were examined by flow cytometry. The positive rate of cyclin D1, p53 protein and aneuploidy was 62. 5%( 25/ 40) , 75% ( 30/ 40) and 77. 5%( 31/ 40) respectively. The levels of cyclin D1 protein and p53 protein in lung cancer tissues were significantly higher than those in normal lung tissues ( P < 0. 01) . Overexpression of cyclin D1, p53 protein and aneuploidy was related with tissue types, pathological grade, lymphatic metastasis and survival time. Cyclin D1 protein and p53 protein play an important role in carcinogenesis of the lung. It is valuable to determine cyclin D1, p53 protein and aneuploidy for judging malignancy and prognosis of lung cancer patients.
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