Abstract
Role of Cyclic Nucleotide Phosphodiesterases in Inner Ear and Hearing.
Highlights
Reviewed by: Andy Groves, Baylor College of Medicine, United States Daniel John Brown, University of Sydney, Australia
Though current knowledge remains limited, understanding the role of PDEs in the inner ear holds a great potential to develop novel treatment modalities for hearing loss and decrease the prevalence of deafness caused by ototoxicity
PDE4D, PDE5, and PDE3 have all been targeted by PDE inhibitors in an attempt to treat other diseases (Turner et al, 2016; Knott et al, 2017; Maier et al, 2017; Wu et al, 2017), though these drugs are suspected to be ototoxic
Summary
Reviewed by: Andy Groves, Baylor College of Medicine, United States Daniel John Brown, University of Sydney, Australia. PDEs aid in the regulation of secondary messengers, cyclic adenosine monophosphate (cAMP), and cyclic guanosine monophosphate (cGMP), through the degradation of phosphodiester bonds (Huang et al, 2010; Ahmad et al, 2015; Epstein, 2017). These secondary messengers, cAMP and cGMP, are vital components of various cell signaling pathways, making their regulation by PDEs important to numerous biological processes (Weber et al, 2017; Yarwood et al, 2017).
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