Abstract
Cholinergic stimualtion of rat submandibular gland slices resulted in a rapid increased in the level of cyclic GMP. This increase was dependent upon the presence of Ca 2+ and a phosphodiesterase inhibitor. Adrenergic agonists did not produce a significant elevation of cyclic GMP. The addition of Ca 2+ to slices preincubated with the divalent ionophore A23187 caysed a rapid rise in cyclic GMP levels which were unaffected by chrolinergic stimulation. While these results could support a funcntion for cyclic GMP in cholinergic-mediated K +-release these glands, they do not support a role for this nucleotide in α-adrenergic agonist-induced k +-release or protease secretion.
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