Role of C-Reactive Protein (CRP) as a Predictive Marker of Anastomotic Leak in Colorectal Surgery: Is it Still Reliable?

Abstract

Introduction: Anastomotic leaks after colorectal surgery is associated with serious morbidity and early diagnosis is critical. C-reactive protein (CRP) on postoperative day (POD) 3 to 5 has been described as a good predictor of anastomotic leak. Therefore, this study aims to review if CRP level of greater than 150mg/l is a reliable predictor of anastomotic leak. 1.2. Methodology: The study was conducted using a prospectively held database from Department of Colorectal Surgery, Singapore General Hospital. From 1 January 2011 to 31 October 2017, all patients who had anastomotic leaks after colorectal resection surgery were analysed retrospectively. Patients without postoperative CRP levels were excluded.