Abstract
Background: Corona viruses are not new to us, and there are 15 different variants known to us. In the last 20 years, this is the fourth coronavirus outbreak, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seems to be the deadliest among all, with the ability to continue producing more contagious variants. In this mini-review, we highlighted the genotypic variance of the pathogenesis of COVID-19. 
 Methodology: The article tracks the history and the genotypic variance of Corona virus. The literature was searched using the terms COVID-19, SARS-CoV-2, Corona virus, genotypic variance etc. via Google Scholar, and PubMed.
 Results: Comparative modelling and molecular studies revealed some essential variations in the intermolecular interaction between Angiotensin-converting enzyme 2 (ACE-2) alleles and SARS-CoV-2 spike protein. This shows an interesting result for two ACE-2 alleles, rs73635825 (S19P) and rs143936283 (E329G), their low binding affinity and lack of some of the critical residues in the complex formation with SARS-CoV-2 spike protein. This may be suggestive of intrinsic resistance to some scale against the SARS-CoV-2 infection.
 Conclusion: The SARS-CoV-2 S protein appears to be a promising immunogen for protection, but its role in preventing transmission is still unclear.
Highlights
The emergence of Coronaviruses has occurred twice in the 21st century and causes worldwide epidemics and pandemics
A third outbreak detected in December 2019 from China has been identified as another variant of coronavirus, named COVID-19 by the World Health Organization (WHO)[1,2,3]
SARS-CoV-2, which was recently identified as the cause of the Coronavirus Illness Pandemic of 2019 (COVID-19), has been classified as a zoonotic disease[7,8]
Summary
The emergence of Coronaviruses has occurred twice in the 21st century and causes worldwide epidemics and pandemics. Understanding this challenging relationship between zoonotic diseases needs to be evaluated for the economic influences of illness on domestic species such as cattle, along with the human health impacts[6] SARS-CoV-2, which was recently identified as the cause of the Coronavirus Illness Pandemic of 2019 (COVID-19), has been classified as a zoonotic disease[7,8].
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