Abstract
Background: Neuroimaging provides essential information as evidence of previous injuries, specific abnormalities that could indicate a group or a particular disease in babies with global developmental delay. The objectives is to assess the difference of corpus callosal size in various regions of the corpus callosum in cases of children with developmental delay and to know the etiology using MRI. Subjects and Methods: My study includes 102 children between 1 to 6 years of age among which 51 children are cases having signs and symptoms of developmental delay and 51 children are controls i.e. healthy babies. They underwent MRI in the Department of Radiology, JJM Medical College, Davangere in whom corpus callosum is imaged on sagittal MR sections and its size is calculated in different regions. Results: Abnormalities of the corpus callosum like thinning and agenesis were observed in 55.5% (N=27) in the study group, and none of the patients in the control group. Partial corpus callosal agenesis was present in 3.9% of patients. Complete agenesis in 3.9% of patients. Thinning of the corpus callosum was seen in 45% of patients who were in the study group. Conclusion: The current study suggests that corpus callosal abnormalities, including brain changes, is useful in knowing the etiology of global developmental delay.
Highlights
Neuroimaging provides essential information as evidence of previous injuries, specific abnormalities that could indicate a group or a particular disease in babies with global developmental delay.The term Global Developmental Delay is commonly used by clinicians which means a significant delay in two or more of the four main developmental domains
This is a hospital-based case-control study which was conducted with a sample size of 102 children between 1 to 6 years of age, for a period of 1 year from June 2018 - June 2019, who had clinical signs and symptoms of developmental delay and who were referred to Department of Radiology, JJM Medical College, Davangere
Abnormalities of the corpus callosum like thinning and agenesis were observed in 55.5% (N=27) in the study group and none of the children in the control group
Summary
Neuroimaging provides essential information as evidence of previous injuries, specific abnormalities that could indicate a group or a particular disease in babies with global developmental delay. The term Global Developmental Delay is commonly used by clinicians which means a significant delay in two or more of the four main developmental domains. It is significant when there is a deficit in performance of at least 2SD below the age-appropriate mean on accepted standardized assessment tests. MRI is a handy tool in identifying corpus callosal abnormalities. The degree of development of the corpus callosum can be used as an indicator to determine the period of fetal growth where the insult has occurred. The degree of development of the corpus callosum can be used as an indicator to determine the period of fetal growth where the insult has occurred. [3]
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