Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis

Abstract

AbstractBackground: Extrahepatic cholestasis is a common prob-lem worldwide and faced in daily practice however it's etiology has a wide range, before starting treatement it is mandatory to reach the cause of the disease. Investigative tools such as computerized tomography, magnetic resonance cholangiopan-creatography etc are expensive, not available in every centers, moreover their accuracy not reaching 100%.Aim of Study: To analyse the role of complete blood count parameters namely RDW, MPV, PDW, PCT, N/L ratio, P/L ratio which are cheap and already available in 1ry care centers in assessment of extrahepatic cholestasis.Patients and Methods: It is a cross-sectional comparative descriptive study conducted during a period of one year starting from 1/3/2016 to 28/2/2017 at Al-Rajhy Liver Hospital, Assiut University Hospitals, on patients presented with defin-itive evidence of extrahepatic cholestasis by clinical exami-nation, laboratory evidence and trans-abdominal ultrasonog-raphy.Results: Thirty eight patients having extrahepatic cholesta-sis were included in the final analysis with a mean age of 47 years of them 14 patients were male. And 10 cases were taken as a control group of them 6 cases were male. Comparing between different etiological types of extrahepatic cholestasis as regards six parameters of the complete blood pictures namely RDW, MPV, PDW, PCT, N/L ratio, P/L ratio shows no significant differences between them. But MPV and PDW were significantly elevated in malignant distal group than control group.Conclusion: Complete blood count parameters namely RDW, MPV, PDW, PCT, N/L ratio, P/L ratio have no significant role in the differentiation between different etiologies of extrahepatic cholestasis. But MPV and PDW were significantly elevated in malignant distal extrahepatic cholestasis than cases without hyperbilirubinemia.