Abstract
Role of complete blood count, antioxidants, and total antioxidant capacity in the pathophysiology of acute coronary syndrome
Highlights
Acute Coronary Syndrome (ACS) is the single-most important contributor to the causes of deaths among the group of disorders of the heart and blood vessels that are associated with Cardiovascular Diseases (CVD) (Benjamin et al, 2019)
The degree of arterial blockage caused by the thrombus determines the amount of myocardial damage and distinguishes the three types of ACS: Unstable Angina (UA) or partial occlusion with no myocardial damage; Non-ST Elevation Myocardial Infarction (NSTEMI) due to partial occlusion with myocardial damage, and ST-Elevation Myocardial Infarction (STEMI) caused by complete occlusion with myocardial damage
Significant differences in the proportion of current smokers, hypertension, breathlessness, and family history of CVD were observed between the ACS patients and control groups, while non-significant variations in the body mass index and pulse rate were observed between the study groups
Summary
Acute Coronary Syndrome (ACS) is the single-most important contributor to the causes of deaths among the group of disorders of the heart and blood vessels that are associated with Cardiovascular Diseases (CVD) (Benjamin et al, 2019). The most suggestive underlying cause of ACS is atherosclerosis, a silent progressive plaque formation process in the coronary arteries, initiated by chronic and acute overproduction of Reactive Oxygen Species (ROS) under the oxidative stress condition resulting in thrombus formation (Madamanchi et al, 2005; and Sanchis-Gomar et al, 2016). A recent study indicated that most the cellular components of the Complete Blood Count (CBC) are involved in the pathogenesis of atherosclerosis which in turn plays a role in the aetiology of CVD (Lassale et al, 2018)
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