Role of Combinatorial, Medicinal & Biological Chemistry in Drug Discovery Development: An Introduction

Abstract

Combinatorial chemistry, a new approach for greatly reducing the time for the discovery of newer organic motifs, has been developed over the last few years. Combinatorial chemistry (Figure 1) is a technique for creating huge numbers of biologically potent motif and their hybrids, then rapidly screening them for desirable properties 1. Almost pharmaceutical and agrochemical industries uses this strategy because of the potential for immense reducing in time and cost, and several drug candidates presently in clinical trials are products of this methodology. Drug discovery process (Figure 2 & 3) is long, time and money intensive process [1]. This science of has found application in the production of molecules of commercial interest in the construction of newer pharmacological active therapeutic agents derived from rational drug design, into synthesize complex natural molecules, in the finding innovative approaches to render this chemical science more efficient [2,3]. The development of newer pharmaceuticals is currently a critical and challenging task to the pharmaceutical industry. The vital interest of the medicinal and agrochemical industries in organic synthesis is often related with their natural occurrence. Similarly, medicinal and pharmaceutical field, there has always been and continue to be a need for newer chemical entities with diverse pharmacophoric properties. Many works are still needed to minimize the time, expenditure, and attrition rate in the drug discovery process simultaneously addressing the huge unmet medical need across the world.