Abstract
Objective:to evaluate the frequency of axillary lymph node metastasis (detected at routine pathomorphological examination) in order to determine the group of patients who do not require lymph node surgery.Materials and methods.We analyzed medical records of 485 patients with breast cancer and no signs (either clinical or instrumental) of regional lymph node involvement who underwent surgery at the first stage of their treatment.Results and conclusion.In patients with cN0 cancer, only the size of primary tumor ≤1 cm was found to be a significant factor indicating that regional lymph nodes are not involved (in addition to palpation, ultrasound, mammography, and spiral x-ray computed tomography of the chest). In patients with сТ1c cancer, the majority of standard immunohistochemical markers cannot yet be used as predictors of regional lymph node involvement. However, tumor differentiation grade G1 is rather an exclusion, which in combination with the size of the primary tumor сТ1c can also be considered as a significant prognostic factor.
Highlights
Role of clinical and morphological data in prediction of regional lymph node involvement in early-stage breast cancer
Objective: to evaluate the frequency of axillary lymph node metastasis in order to determine the group of patients who do not require lymph node surgery
In patients with cN0 cancer, only the size of primary tumor ≤1 cm was found to be a significant factor indicating that regional lymph nodes are not involved
Summary
Проанализированы истории болезни 485 больных ранним раком молочной железы без клинико-инструментальных признаков поражения регионарных лимфатических узлов, которым 1‐м этапом проводилось оперативное вмешательство. Роль оценки совокупности клинико-морфологических данных для прогнозирования поражения регионарных лимфатических узлов при раннем раке молочной железы. We analyzed medical records of 485 patients with breast cancer and no signs (either clinical or instrumental) of regional lymph node involvement who underwent surgery at the first stage of their treatment. In patients with cN0 cancer, only the size of primary tumor ≤1 cm was found to be a significant factor indicating that regional lymph nodes are not involved (in addition to palpation, ultrasound, mammography, and spiral x-ray computed tomography of the chest). For citation: Shatova Yu.S., Vashchenko L.N., Bosenko E.S. et al Role of clinical and morphological data in prediction of regional lymph node involvement in early-stage breast cancer. Биопсия сигнального лимфатического узла (БСЛУ) является рутинной процедурой в большинстве развитых стран мира
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