Abstract
The fatty acid shuttle for the transport of reducing equivalents into mitochondria was reconstituted in vitro . Externally added citrate increased the activity of this shuttle 30–40%. Citrate also stimulated the activity in the absence of added fatty acid (endogenous rate). The effect of citrate was prevented neither by inhibition of citric acid cycle activity nor by blocking citrate transport into the mitochondria. Inhibition of citrate efflux from the mitochondria impaired shuttle activity. A fatty acid elongation system in the outer membrane, which is stimulated by citrate, may be rate-limiting for the fatty acid shuttle.
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