Abstract
BackgroundBladder cancer is a common malignancy in Egypt. A history of urinary tract infection can be considered as a risk factor for bladder cancer. Escherichia coli (E. coli) infection is responsible for 70% of urinary tract infection. This study aimed to evaluate the role of chronic E. coli infection during bladder carcinogenesis. In order to achieve this aim, we investigated the histopathological changes in bladder tissue and measured the level of nuclear factor kappa p65 (NF-κBp65), Bcl-2 and interleukin 6 (IL-6) in four groups each consisting of 25 male albino rats except of control group consisting of 20 rats. The first group was normal control group, the second group was infected with E. coli, the third group was administered nitrosamine precursor, and the forth group was infected with E. coli and administered nitrosamine precursor.ResultsThe histopathological examination revealed that E. coli infected group was able alone to produce some histopathological changes in bladder tissue and that nitrosamine precursor plus E. coli group showed highest incidences of urinary bladder lesions than the nitrosamine precursor group. NF-κBp65, Bcl-2 and IL-6 levels were significantly higher in nitrosamine precursor plus E. coli group than the other groups.ConclusionThese findings suggested that urinary bladder infection by E. coli may play a major additive and synergistic role during bladder carcinogenesis.
Highlights
Bladder cancer is a common malignancy in Egypt
The histopathological examination revealed that E. coli infected group was able alone to produce some histopathological changes in bladder tissue ranging from inflammation to dysplasia and that nitrosamine precursor plus E. coli group showed highest incidences of urinary bladder lesions than the nitrosamine precursor group and E. coli group
In addition a significant difference was observed among the three groups, with those of group IV showing the highest values
Summary
Bladder cancer is a common malignancy in Egypt. A history of urinary tract infection can be considered as a risk factor for bladder cancer. Escherichia coli (E. coli) infection is responsible for 70% of urinary tract infection. This study aimed to evaluate the role of chronic E. coli infection during bladder carcinogenesis. Carcinoma of the bladder is the most prevalent cancer in Egypt. Nitrate contamination of drinking water was reported as a risk of bladder cancer. Other etiological factors implicated in the development and progression of bladder cancer includes urinary tract infections (UTIs) including bacterial, parasitic, fungal, and viral infections; urinary lithiasis and pelvic radiation [5]. This study aimed to evaluate the possible role of E. coli infection during bladder carcinogenesis and the changes in NF-κB pathway and its related products
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