Abstract
Chinese hamster ovary cells were irradiated with u.v. light and chromatin was isolated and fractionated according to magnesium-solubility in low ionic strength conditions. The minor, magnesium-soluble chromatin fraction was demonstrated to be enriched by over three-fold in transcriptionally active sequences and had proteins associated with it characteristic of transcriptionally active chromatin. Using a sensitive radioimmunoassay for u.v.-induced DNA photoproducts, we have shown that there are no differences in either induction or repair of u.v. DNA photoproducts in chromatin fractions from cells irradiated at low u.v. fluence.
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More From: International journal of radiation biology and related studies in physics, chemistry, and medicine
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