Abstract
Effect of inorganic anions on p- amino [ 3H]hippurate transport in renal basolateral membranes has been studied using the vesicles preloaded with unlabeled p- aminohippurate (countertransport condition). The uptake of p- amino [ 3H]hippurate was stimulated by the outward gradient of unlabeled p- aminohippurate and the labeled substrate was accumulated into the vesicles against its concentration gradient in the presence of Cl −. The substitution of SCN − and SO 4 2− for Cl − in both sides of the vesicles depressed the initial rate and the overshoot magnitude of p- amino [ 3H]hippurate uptake. These results suggest that Cl − may play an important role for the carrier-mediated transport system of organic anion in renal basolateral membranes.
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