Abstract
Lower respiratory tract disease caused by respiratory syncytial virus (RSV) is characterized by profound airway mucosa inflammation, both in infants with naturally acquired infection and in experimentally inoculated animal models. Chemokines are central regulatory molecules in inflammatory, immune and infectious processes of the lung. Previously we have shown that the depletion of MIP-1α/CCL3 reduces lung inflammation and chemokine expression in RSV-infected lung tissue. In this study, we demonstrate that depletion of CCR5 as a receptor for MIP-1α results in upregulation of chemokines and cytokines in RSV-infected lung tissue but had no influence on viral clearance or histopathology compared with the wild type animals. Genetically altered mice with additional deletion of the MIP-1α/CCL3 gene demonstrated an upregulation in the chemokine mRNA expression paralleled by comparable cytokine expression following RSV infection, compared with wild type mice. There was no difference in lung inflammation or viral clearance. Pathology scores were only reduced in mice depleted for MIP-1α/CCL3. These results provide some evidence that the pattern of chemokine expressed in lung tissue determines the severity of lung inflammation during RSV infection.
Highlights
Activation of the HPA axis occurs in order to control potentially deleterious effects of systemic inflammation during sepsis
We sought to compare differences in mortality and length of stay (LOS) between lactic acidosis (LA) and other forms of metabolic acidoses. In this observational pilot study, we reviewed records of 9799 patients admitted to the intensive care unit (ICU) at our institution between 1 January 2001 and 30 June 2002
Multiple Organ Failure (MOF) complicating the sepsis remains the first cause of death in the ICU
Summary
Activation of the HPA axis occurs in order to control potentially deleterious effects of systemic inflammation during sepsis. The aim of the study was to evaluate the effects of PEEP on intrathoracic blood volumes and cardiac function measured by the COLD system in ARDS patients. The objective was to identify risk factors and outcome of pregnant women who required intensive care This pilot study aims to find stress (S) and other personality traits (physical symptoms [PS], anger [A]) among the ICU staff, and any existing correlation between them and length of working time (LWT) in the ICU and with educational level (EDL). The role of Drotrecogin alfa (activated) (recombinant human activated protein C [rhAPC]) in modulating microvascular coagulation through the inhibition of thrombin generation has been well studied in experimental and clinical settings of severe sepsis, little is known about its direct anti-inflammatory effects on vascular endothelial cells. The aim is to determine whether an effective lifestyle adaptation program post CABG could enhance the quality of life of the CABG patient
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