Abstract
Background The cGMP pathway regulates a large spectrum of physiological processes including metabolism. Our aim is to elucidate the cGMP signaling cascade in adipose tissue. Two types of fat tissue can be distinguished in mammals: white adipose tissue (WAT), which is the biggest storage of energy, and brown fat (BAT) that can dissipate energy as heat (non-shivering thermogenesis). We and others found that cGMP enhances differentiation of brown and white adipocytes [1-4].
Highlights
The cGMP pathway regulates a large spectrum of physiological processes including metabolism
Using gain- and loss-of-function models, we found that PKG is the major receptor for cGMP in brown adipocytes
We investigated the downstream targets of PKG and found a novel negative feedback loop that regulates cGMP levels
Summary
The cGMP pathway regulates a large spectrum of physiological processes including metabolism. Our aim is to elucidate the cGMP signaling cascade in adipose tissue. Two types of fat tissue can be distinguished in mammals: white adipose tissue (WAT), which is the biggest storage of energy, and brown fat (BAT) that can dissipate energy as heat (non-shivering thermogenesis). We and others found that cGMP enhances differentiation of brown and white adipocytes [1-4]
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