Abstract
Cardiovascular diseases are caused by disorders of the heart and blood vessels and it remains the principal cause of death in both developed and developing countries, accounting for roughly 20%. Cardiotoxicity renders the heart unable to efficiently pump blood throughout the body. Oxidative stress resulting from the higher production of free radicals that plays a major role in cardiovascular disease. Cardiotoxicity is described as the harmful effect on the heart caused by various drugs. Anticancer drugs, antipsychotic drugs, methamphetamine, isoproterenol, minoxidil, cyclosporine A, azithromycin, tilmicosin etc., can able to produce cardiotoxicity by various mechanisms. In this context, we have made an attempt to explore the therapeutic drugs induced cardiotoxicity in experimental animal models with their dose and mechanism.
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