Abstract
The role of the central histaminergic system in depression was studied by using swimming despair test in mice - a behavioural model of depression. In this test, immobility of mice reflects a state of depression. Intracerebral (ic) injection of histamine (50–200 μg) increased significantly the immobility. The H 1-receptor blocker mepyramine (2.5–20 mg/kg ip) had no effect while H 2-receptor blocker cimetidine (100–200 μg ic) caused a significant decrease in immobility. The histamine induced facilitation was blocked completely by cimetidine and antidepressant drugs-imipramine and desipramine, but remained unaffected in mice pretreated with mepyramine or atropine. The H 2agonist impromidine (20–40 μg ic) also enhanced significantly, the immobility which was blocked by cimetidine and antidepressant drugs. It has been concluded that central H 2-receptors facilitate depression and antidepressant drugs block central H 2-receptors.
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