Abstract
A MAJOR factor preventing the more widespread clinical application of intestinal transplantation is the unusual frequency and severity of allograft rejection. Using a murine model of intestinal transplantation, we have previously shown that allograft rejection was dependent on ab, but not gd, T cells and that this rejection could be significantly inhibited by tacrolimus, an immunosuppressive agent with potent anti-T-cell properties. In this study, the murine model was used to examine further the role of CD8 and CD4 T cells in the rejection of intestinal allografts.
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