ROLE OF CD163+ TUMOUR ASSOCIATED MACROPHAGES IN PROGNOSTICATION OF PATIENTS DIAGNOSED OF HODGKIN'S LYMPHOMA: A PROSPECTIVE COHORT STUDY

Abstract

Hodgkin's lymphoma (HL) constitutes around 30% of all lymphomas . IPS is used for the risk stratication of advanced stage HL but it lack applicability to the early stage cases ..In this prospective cohort study, we aim to conrm the relationship between CD68+TumourAssociated macrophages with treatment response (interim as well as end of treatment) of HL treated with the standard chemotherapy and radiotherapy regimens. A total of 50 patients were recruited over a period of 18 months and the patients were followed up in the hematology clinic and interim treatment responses as well as end of treatment response were assessed. Correlation of the CD163+Tumour Associated Macrophages and the treatment response showed that the Higher Percentages of CD163+Tumour Associated Macrophages were associated with more advanced stages.. Univariate analysis showed that there was no signicant correlation of interim treatment response as well as end of treatment response with CD163+Tumour Associated macrophages levels .