Abstract

Caveolins are the major component proteins of the caveolae, and they are also the essential proteins to carry out the physiological functions of caveolae. Caveolins are expressed in smooth muscle cells, endothelial cells, and adipocytes. Caveolae are not only involved in the basic physiological processes, such as cellular fat intake, endocytosis, and pinocytosis, but also play a very important role in cell signal transduction and transport and permeability of macromolecular substance. With the in-depth research on the molecular structure and biochemical function of caveolins, increasing studies have shown that caveolae and their main component caveolins play an important role in the pathophysiological process of cerebrovascular diseases. This article reviews the roles of caveolins in the blood-brain barrier destruction after cerebral ischemia. Key words: Stroke; Brain Ischemia; Blood-Brain Barrier; Brain Edema; Caveolin 1

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