Abstract
During 1962 and 1963, in Dacca, East Pakistan, families which were either household contacts of cholera suspects or were of neighbouring (control) households were investigated to determine the role of symptom-free carriers of Vibrio cholerœin the transmission of infection to family contacts. 10 families (in 6 " contact" and 2 control households) with at least one member who had an asymptomatic infection on initial bacteriological examination and with no episodes of vomiting and/or diarrhoea before detection of the symptom-free carrier, were examined for 11-32 days. There were no cases of cholera among the fifty-nine family contacts; nor were any further symptom-free carriers detected among the forty-one contacts who were examined bacteriologically. Direct family contacts of cholera cases might be expected to have a secondary attack-rate of 9%, and a further 10% of them might have an asymptomatic infection: thus it seems that the symptom-free carrier is very much less important than the active cholera case in the transmission of V. cholerœ.
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