Abstract
Introduction and ObjectiveThe keratocystic odontogenic tumor is a benign but aggressive neoplasm. As enucleation alone obtains high recurrence rates, some adjuvant treatments such as Carnoy’s solution have been proposed. The aim of this study is to evaluate the reduction of recurrences with the use of Carnoy’s solution as adjuvant in the treatment of keratocystic odontogenic tumors.Material and MethodsAn electronic search in Pubmed (MEDLINE), ScienceDirect and Cochrane databases was conducted with the key words “odontogenic keratocyst”, “keratocystic odontogenic tumor”, “carnoy’s solution”, “treatment” and “enucleation”. The inclusion criteria were clinical studies using Carnoy’s solution as adjuvant for the treatment of keratocystic odontogenic tumors, published in English, including at least 10 patients. Articles with an unclear reporting of the treatment applied, nonhuman studies, case reports and lesions associated to Gorlin-Goltz syndrome were excluded.ResultsAll the studies included were case series. The recurrence rate of enucleation ranged from 0% to 58.8%. With the only use of Carnoy’s solution as adjuvant treatment to the enucleation, recurrences varied from 0% to 100%. The use of ≥ 2 adjuvant treatments reduced the range between 0% and 7.9%.ConclusionsThe use of Carnoy’s solution as adjuvant therapy for the treatment of keratocystic odontogenic tumor has a grade C recommendation. Key words:Carnoy’s solution, keratocystic odontogenic tumor, treatment, recurrence.
Highlights
Introduction and ObjectiveThe keratocystic odontogenic tumor is a benign but aggressive neoplasm
The later was renamed as keratocystic odontogenic tumor (KOT) by the World Health Organization (WHO) in 2005 that is a benign but aggressive neoplasm of odontogenic origin, histologically characterized by a thin parakeratinized stratified squamous epithelium (1-9)
Enucleation is the treatment of choice it can result in a 60% of recurrences (9)
Summary
Introduction and ObjectiveThe keratocystic odontogenic tumor is a benign but aggressive neoplasm. The aim of this study is to evaluate the reduction of recurrences with the use of Carnoy’s solution as adjuvant in the treatment of keratocystic odontogenic tumors. The inclusion criteria were clinical studies using Carnoy’s solution as adjuvant for the treatment of keratocystic odontogenic tumors, published in English, including at least 10 patients. An incisional or excisional biopsy, or a fine-needle aspiration biopsy are the most used techniques to obtain a sample (2), the presence of inflammatory infiltrate can impair the diagnosis and give rise to false negatives (1,2) It appears as a unilocular or multilocular well-defined lesion with scalloped margins (10). The aim of this systematic review was to evaluate the reduction of recurrences associated to the application of Carnoy’s solution as adjuvant in the treatment of keratocystic odontogenic tumors
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