Abstract
There is much evidence that phospholipids metabolism is related to intracellular signal transmission system (1,2,3). Besides adenosine 3′:5′-cyclic monophosphate (cyclic AMP) and protein kinase A system, phosphoinositides metabolism has recently been emphasized as an intracellular calcium messenger system which modulates cytosolic free calcium concentration, and mediates the subsequent transmission of signals (3).Phospholipase C, which is activated by receptor mediated mechanisms, has been found to initiate the intracellular transmission of signals. Furthermore, in concerting with diacylglycerol lipase, phospholipase C provides arachidonate for prostaglandin (PG) generation (4,5). In conjunction with this, phospholipase A2is also known to directly hydrolyze sn-2-position of phospholipids, increasing free arachidonate pool available for PG synthesis. Thus, it is conceivable that phospholipases in cardiovascular system influence the regulatory mechanism for hemodynamics and body fluid homeostasis through their intracellular actions.
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